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M9640845.TXT
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1996-03-04
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Document 0845
DOCN M9640845
TI EBV-associated lymphoproliferative syndrome with a distinct 69 base-pair
deletion in the LMP-1 oncogene.
DT 9604
AU Klein C; Rothenberger S; Niemeyer C; Bachmann E; Odermatt B; Bohm N;
Brandis M; Knecht H; University Children's Hospital, Freiburg, Germany.
SO Br J Haematol. 1995 Dec;91(4):938-40. Unique Identifier : AIDSLINE
MED/96136096
AB We describe an immunocompetent 12-year-old boy with chronic EBV
infection and lymphoid interstitial pneumonitis. Lymph node biopsies
showed effacement of the architecture with polymorphic cellular
infiltrates, consisting predominantly of T cells and natural killer
cells. No clonal rearrangement of TCR or immunoglobulin genes was seen.
DNA was extracted from hilar lymph nodes; sequencing of the carboxy
terminal region of the latent membrane protein 1 (LMP-1) oncogene
revealed a 69 base-pair deletion and four point mutations.
Immunosuppressive treatment with prednisone and cyclosporine reversed
the lymphadenopathy.
DE Base Composition Base Sequence Case Report Child
Cyclosporine/THERAPEUTIC USE DNA Primers/GENETICS Electrophoresis,
Agar Gel *Gene Deletion Herpesviridae Infections/DRUG
THERAPY/*GENETICS/PATHOLOGY Herpesvirus 4, Human/*IMMUNOLOGY Human
Lung Diseases, Interstitial/DRUG THERAPY/GENETICS/PATHOLOGY Lymph
Nodes/PATHOLOGY Male Molecular Sequence Data Point Mutation
Polymerase Chain Reaction Prednisolone/THERAPEUTIC USE Support,
Non-U.S. Gov't Tumor Virus Infections/DRUG THERAPY/*GENETICS/PATHOLOGY
Viral Matrix Proteins/*GENETICS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).